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20:4420:44, 19 May 2026 diff hist +17,867 N User:MDElliottMD/Sandbox/CYP2D6 Retrofit CYP2D6 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (49 rows: opioid prodrugs, TCAs, SSRIs/SNRIs, antipsychotics, beta blockers, antiarrhythmics, antiemetics, tamoxifen, atomoxetine, perhexiline, antihistamines, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for codeine/tramadol/risperidone/tamoxifen/venlafaxine). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart In...
20:1320:13, 19 May 2026 diff hist +14 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
20:0820:08, 19 May 2026 diff hist +67 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
20:0120:01, 19 May 2026 diff hist +123 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
19:5019:50, 19 May 2026 diff hist +7,014 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
19:3119:31, 19 May 2026 diff hist +13,862 N User:MDElliottMD/Sandbox/CYP2C9 Sandbox-save CYP2C9 enzyme entity page (4th of 10 pharmacogenomics enzyme pages). History-first spine: Rettie 1992 Seattle / S-warfarin / CYP2C9. Three CPIC guidelines cited: warfarin 2017 PMID 28198005, phenytoin 2020 PMID 32779747, NSAIDs 2020 PMID 32189324. Plus Rettie 1992 PMID 1581537, Sullivan-Klose 1996 PMID 8873220 (CYP2C9*3 / tolbutamide), Aithal 1999 PMID 10073515 (Lancet warfarin dose / bleeding). All 6 PMIDs NCBI-eutils-verified. Final home Enzyme:CYP2C9 once namespace registered.
19:2219:22, 19 May 2026 diff hist +28 Category:Κ-Opioid Receptor Agonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Z-Drugs (Non-Benzodiazepine Hypnotics) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Xanthines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Tryptamines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Triptans (5-HT1B/1D Agonists) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Tricyclic Antidepressants (TCAs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Third-Generation Antipsychotics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Thioxanthenes Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Thienodiazepines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Synthetic opioids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Synthetic Cannabinoids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Sodium channel blockers Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Serotonin Antagonist and Reuptake Inhibitors (SARIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Semisynthetic opioids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Selective Serotonin Reuptake Inhibitors (SSRIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Selective MAO-B inhibitors Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Sedative-Hypnotics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Second-generation antihistamines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Second-Generation Antipsychotics (SGAs / Atypicals) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:SV2A ligands Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +19 Category:Rhapsodica Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Reversible MAO-A inhibitors (RIMAs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Research Materials Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Racetams Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Pyrrolidinophenones Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Psychostimulants Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Psychedelics Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +19 Category:Plant Medicines Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +19 Category:Phytocannabinoids Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Phenothiazines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Phenethylamines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Pharmaceutical Cannabinoids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +47 Category:Phantastica Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Peptide Nootropics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Partial Mu-Opioid Agonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +47 Category:Pacifica Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:PDE5 Inhibitors Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Orexin Receptor Antagonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +47 Category:Opioids Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Opioid agonist therapy Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Opioid Receptor Modulator + NMDA Antagonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
19:2219:22, 19 May 2026 diff hist +28 Category:Opioid antagonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
19:2219:22, 19 May 2026 diff hist +28 Category:Norepinephrine–Dopamine Reuptake Inhibitors (NDRIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current

19 May 2026