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A user with 5,671 edits. Account created on 9 May 2026.
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20 May 2026

  • 00:3200:32, 20 May 2026 diff hist +2,482 N Phenotype:CYP2B6 ultrarapid metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +2,563 N Phenotype:CYP2B6 rapid metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +2,781 N Phenotype:CYP2B6 normal metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +3,154 N Phenotype:CYP2B6 intermediate metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,525 N Phenotype:CYP2B6 poor metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +2,974 N Phenotype:CYP2C9 normal metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,766 N Phenotype:CYP2C9 intermediate metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +5,786 N Phenotype:CYP2C9 poor metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +3,851 N Phenotype:CYP2C19 ultrarapid metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,030 N Phenotype:CYP2C19 rapid metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +3,097 N Phenotype:CYP2C19 normal metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,693 N Phenotype:CYP2C19 intermediate metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +5,768 N Phenotype:CYP2C19 poor metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,271 N Phenotype:CYP2D6 ultrarapid metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +3,980 N Phenotype:CYP2D6 normal metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:3200:32, 20 May 2026 diff hist +4,733 N Phenotype:CYP2D6 intermediate metabolizer Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...
  • 00:1000:10, 20 May 2026 diff hist 0 MediaWiki:Common.css Restore css content model clobbered by maintenance edit.php current Tag: content model change

19 May 2026

  • 23:2823:28, 19 May 2026 diff hist +6,335 N Phenotype:CYP2D6 poor metabolizer Sandbox-save CYP2D6 poor metabolizer phenotype page as the template exemplar for the pharmacogenomic phenotype subpage set (26 pages across 7 enzymes with CPIC phenotype schemes). Definitional satellite page of Enzyme:CYP2D6: lead defines the phenotype + the two-directional clinical principle (activation case vs clearance case); sections for genotype basis, population frequency, clinical consequences, phenocopying. CPIC opioid guideline cited PMID 33387367 (verified). Deliberate deviation fro...
  • 23:2723:27, 19 May 2026 diff hist +782 N Category:CuratedCategoryPage Create CuratedCategoryPage maintenance marker (hidden category) per canonical category-page structure current
  • 23:2723:27, 19 May 2026 diff hist +654 MediaWiki:Common.css Auto-list hide rule: add Category:CuratedCategoryPage, make skin-independent and !important, per home-claude category-page spec
  • 23:1823:18, 19 May 2026 diff hist +33 Category:Drug-metabolizing enzymes Add Category:CuratedCategoryPage marker tag per interface-claude 2026-05-20. This marker lets MediaWiki:Common.css suppress MediaWiki's auto-generated 'Pages in category' list, which otherwise renders the member list a second time (machine-formatted) below the curated 'Enzymes indexed' section. Marker is the general non-MedCategory equivalent of the existing MedCategoryFull marker. No prose change.
  • 23:0123:01, 19 May 2026 diff hist +5,616 Category:Drug-metabolizing enzymes Rewrite category intro: replace the wiki-plumbing lead with a descriptive, history-first account of what a drug-metabolizing enzyme is. Covers the cytochrome P450 naming (Omura and Sato 1964, the 450 nm absorption peak, PMID 14209971), the phase-I / phase-II framework, the mixed-function-oxidase mechanism, the enzyme families, and the detoxification-versus-bioactivation duality (Pott 1775 chimney-sweep scrotal cancer as the historical thread; CYP1A/CYP3A4/CYP2E1 carcinogen activation as the m...
  • 22:3922:39, 19 May 2026 diff hist +3,660 N Category:Drug-metabolizing enzymes Create Category:Drug-metabolizing enzymes: curated index of the 11 enzyme entity pages (8 CYPs + UGT1A1 + TPMT + NUDT15) at their canonical Pharmacopedia: sandbox location, grouped by enzyme family, with scope notes distinguishing enzymes from transporters and non-enzyme variant loci. Parent Category:Pharmacogenomics.
  • 22:3922:39, 19 May 2026 diff hist −19,919 User:MDElliottMD/Sandbox/UGT1A1 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −17,395 User:MDElliottMD/Sandbox/TPMT Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −14,655 User:MDElliottMD/Sandbox/NUDT15 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −21,651 User:MDElliottMD/Sandbox/CYP3A4 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −17,801 User:MDElliottMD/Sandbox/CYP2D6 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −21,014 User:MDElliottMD/Sandbox/CYP2C9 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −17,320 User:MDElliottMD/Sandbox/CYP2C19 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −15,158 User:MDElliottMD/Sandbox/CYP2B6 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist −17,538 User:MDElliottMD/Sandbox/CYP1A2 Redirect to canonical enzyme sandbox location. This User: page was a cross-session sandbox-location duplication artifact; the canonical enzyme sandbox pages live under Pharmacopedia:Pharmacogenomics sandbox/Enzyme <NAME>. Content (full retrofitted version) is preserved at the canonical title. current Tag: New redirect
  • 22:3922:39, 19 May 2026 diff hist +14,721 N Enzyme:NUDT15 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +17,459 N Enzyme:TPMT Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +19,985 N Enzyme:UGT1A1 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +10,606 Enzyme:CYP3A4 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +15,075 N Enzyme:CYP2E1 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +8,191 Enzyme:CYP2D6 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +5,291 Enzyme:CYP2C19 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +21,080 N Enzyme:CYP2C9 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +13,652 N Enzyme:CYP2C8 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +15,224 N Enzyme:CYP2B6 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:3922:39, 19 May 2026 diff hist +17,604 N Enzyme:CYP1A2 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
  • 22:1122:11, 19 May 2026 diff hist +15,224 N User:MDElliottMD/Sandbox/CYP2B6 Sandbox-save CYP2B6 enzyme entity page (9th pharmacogenomics enzyme page). History-first spine: the rehabilitation of a long-neglected enzyme - Lang/Klein/Zanger Dr. Margarete Fischer-Bosch Institute Stuttgart 2001 polymorphism survey PMID 11470993. 16-row collapsible-sortable substrate table (efavirenz canonical, bupropion probe, methadone, cyclophosphamide/ifosfamide bioactivation, ketamine, others). Full PM/IM/NM/RM/UM phenotype classification per CPIC efavirenz guideline. Major variant *6...
  • 22:0322:03, 19 May 2026 diff hist +17,604 N User:MDElliottMD/Sandbox/CYP1A2 Sandbox-save CYP1A2 enzyme entity page (8th pharmacogenomics enzyme page). History-first spine: Anthony Conney enzyme-induction research (Hoffmann-La Roche, Nutley NJ), 1982 Clowes Memorial Lecture PMID 6814745, AhR induction mechanism. 28-row collapsible-sortable substrate table (clozapine/olanzapine/theophylline/tizanidine headline substrates; caffeine probe; antidepressants, triptans, others). Phenotype section: honest no-PM/IM/NM-bedside-classification (like CYP3A4); variability dominated...
  • 21:4421:44, 19 May 2026 diff hist +14,721 N User:MDElliottMD/Sandbox/NUDT15 Sandbox-save NUDT15 enzyme entity page (7th pharmacogenomics enzyme page, parallel to TPMT). History-first spine: Asan Medical Center Seoul 2014 GWAS in Korean IBD cohort discovering NUDT15 rs116855232 Arg139Cys, Yang 2014 Nat Genet PMID 25108385; Moriyama 2016 Nat Genet mechanism (St. Jude) PMID 26878724; Yang 2015 JCO ALL extension PMID 25624441; Moriyama 2017 Blood diverse-ancestry alleles PMID 28659275; Relling 2019 CPIC TPMT+NUDT15 PMID 30447069; PharmGKB Whirl-Carrillo 2021 PMID 3421602...
  • 21:3521:35, 19 May 2026 diff hist +17,459 N User:MDElliottMD/Sandbox/TPMT Sandbox-save TPMT enzyme entity page (6th pharmacogenomics enzyme page). History-first spine: Weinshilboum & Sladek 1980 Mayo Clinic bimodal-distribution discovery PMID 7191632, one of the foundational pharmacogenetics demonstrations. Lennard 1989 azathioprine-toxicity link PMID 2758725; Krynetski 1995 PNAS TPMT*2 molecular variant PMID 7862671; Loennechen 1998 TPMT*3C PMID 9695718; Relling 2019 CPIC TPMT+NUDT15 thiopurine dosing PMID 30447069. NUDT15 cross-reference section cites Yang 2014 N...
  • 21:0921:09, 19 May 2026 diff hist +19,985 N User:MDElliottMD/Sandbox/UGT1A1 Sandbox-save UGT1A1 enzyme entity page (5th of 10 pharmacogenomics enzyme pages). History-first spine: Gilbert 1901 Paris + Bosma 1995 NEJM Amsterdam closure (UGT1A1*28 promoter TA-repeat discovery). Two CPIC/DPWG guidelines cited: Gammal 2016 CPIC atazanavir PMID 26417955, Hulshof 2023 DPWG irinotecan PMID 36443464. Plus mechanistic refs Iyer 1998 JCI PMID 9466980 (UGT1A1 + SN-38), Innocenti 2004 JCO PMID 15007088 (irinotecan + UGT1A1*28 + neutropenia). Plus Tukey & Strassburg 2000 Annu Rev...
  • 20:4420:44, 19 May 2026 diff hist +17,387 N User:MDElliottMD/Sandbox/CYP2C19 Retrofit CYP2C19 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (32 rows: PPIs, SSRIs, clopidogrel/proguanil activation, voriconazole, diazepam, mephenytoin probe, carisoprodol, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for clopidogrel and proguanil). Plus Comprehensive substrate and interaction tables pointer section. NOTE: also restored three CPIC-guideline ref definitions (cpic-clopidogrel-2022 PMID 350...
  • 20:4420:44, 19 May 2026 diff hist +21,717 N User:MDElliottMD/Sandbox/CYP3A4 Retrofit CYP3A4 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (57 rows: benzodiazepines, calcium channel blockers, statins, immunosuppressants, anti-cancer, macrolides, HIV protease inhibitors, DOACs, opioids, antifungals, PDE5 inhibitors, antihistamines, endogenous steroids, others; tier-tagged major/moderate/minor/partial). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart Indiana University, FDA Drug Dev...
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